St. Louis was founded in 1764 by Pierre Laclede and Auguste Chouteau. It was named after Louis IX of France.
The United States purchased the land in 1803 as part of the Louisiana Purchase.
St. Louis was developed as a major port on the Mississippi River, which marks the border between Missouri and Illinois.
In 1870, St. Louis was ranked as the fourth largest city in the U.S. It separated from St. Louis County in 1877, making it an independent city limiting its political boundaries.
St. Louis is headquarters to multiple publicly traded companies, some of which are Fortune 500 companies.